原创力文档choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma association with survival胆碱激酶α和hexokinase-2蛋白表达在肝细胞癌与生存.pdfVIP
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choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma association with survival胆碱激酶α和hexokinase-2蛋白表达在肝细胞癌与生存
Choline Kinase Alpha and Hexokinase-2 Protein
Expression in Hepatocellular Carcinoma: Association
with Survival
1,2 2 2 2,3
Sandi A. Kwee *, Brenda Hernandez , Owen Chan , Linda Wong
1The Queen’s Medical Center, Honolulu, Hawaii, United States of America, 2 University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, United
States of America, 3 Department of Surgery, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Abstract
Purpose: Hexokinase-2 (HK2) and more recently choline kinase alpha (CKA) expression has been correlated with clinical
outcomes in several major cancers. This study examines the protein expression of HK2 and CKA in hepatocellular carcinoma
(HCC) in association with patient survival and other clinicopathologic parameters.
Methods: Immunohistochemical analysis for HK2 and CKA expression was performed on a tissue microarray of 157 HCC
tumor samples. Results were analyzed in relation to clinicopathologic data from Surveillance, Epidemiology, and End-Results
Program registries. Mortality rates were assessed by Kaplan-Meier estimates and compared using log-rank tests. Predictors
of overall survival were assessed using proportional hazards regression. RESULTS: Immunohistochemical expression of HK2
and CKA was detected in 71 (45%) and 55 (35%) tumor samples, respectively. Differences in tumor HK2 expression were
associated with tumor grade (p = 0.008) and cancer stage (p = 0.001), while CKA expression differed significantly only across
cancer stage (p = 0.048). Increased mortality was associated with tumor HK2 expression (p = 0.003) as well as CKA expression
(p = 0.03) with hazard ratios of 1.86 (95% confidence interval (CI) 1.23–2.83) and 1.59 (95% CI 1.04–2.41), respectivel
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