circadian gene variants and susceptibility to type 2 diabetes a pilot study生理节奏基因变异,对2型糖尿病的易感性试点研究.pdfVIP

Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study 1,2 1,2 3 4 2,5 M. Ann Kelly *, Simon D. Rees , M. Zafar I. Hydrie , A. Samad Shera , Srikanth Bellary , J. 6 6 1,2 3 2 Paul O’Hare , Sudhesh Kumar , Shahrad Taheri , Abdul Basit , Anthony H. Barnett , DIAGRAM consortium, SAT2D consortium 1 College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 2 BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom, 3 Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan, 4 Diabetic Association of Pakistan, Karachi, Pakistan, 5 School of Life and Health Sciences, Aston University, Birmingham, United Kingdom, 6 Warwick Medical School, University of Warwick, Coventry, United Kingdom Abstract Background: Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/ near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants. Methodology/Principal Findings: The pilot study was performed using two genetically homogeneous Punjabi cohorts, one resident