combined impact of lifestyle-related factors on total and cause-specific mortality among chinese women prospective cohort study与生活方式相关的因素共同影响,中国女性死因别死亡率前瞻性群组研究.pdfVIP

Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study 1 1 2 1 2 1 Sarah J. Nechuta , Xiao-Ou Shu , Hong-Lan Li , Gong Yang , Yong-Bing Xiang , Hui Cai , Wong-Ho 3 3 1 1 2 1 Chow , Butian Ji , Xianglan Zhang , Wanqing Wen , Yu-Tang Gao , Wei Zheng * 1 Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 2 Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China, 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America Abstract Background: Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chinese and other non-Western populations. The objective of this study was to quantify the overall impact of lifestyle-related factors beyond that of active cigarette smoking and alcohol consumption on all-cause and cause-specific mortality in Chinese women. Methods and Findings: We used data from the Shanghai Women’s Health Study, an ongoing population-based prospective cohort study in China. Participants included 71,243 women aged 40 to 70 years enrolled during 1996–2000 who never smoked or drank alcohol regularly. A healthy lifestyle score was created on the basis of five lifestyle-related factors shown to be independently associated with mo