comparative proteomic analysis of the phop regulon in salmonella enterica serovar typhi versus typhimurium比较蛋白质组学分析的phop调节子在伤寒沙门氏菌血清型与沙门氏菌感染.pdfVIP

Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 1,2 1,3 4,5 1 1,6 Richelle C. Charles *, Jason B. Harris , Michael R. Chase , Lauren M. Lebrun , Alaullah Sheikh , 1,2 7 1 6 Regina C. LaRocque , Tanya Logvinenko , Sean M. Rollins , Abdullah Tarique , Elizabeth L. 1,2 4 4 4 6 Hohmann , Ian Rosenberg , Bryan Krastins , David A. Sarracino , Firdausi Qadri , Stephen B. Calderwood1,2,8, Edward T. Ryan1,2,5 1 Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 2 Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Harvard Medical School–Partners Healthcare Center for Genetics and Genomics, Cambridge, Massachusetts, United States of America, 5 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, 6 International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 7 Biostatistics Research Center, Tufts Medical Center, Boston, Massachusetts, United States of America, 8 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular inf