ck1ε is required for breast cancers dependent on β-catenin activityck1ε乳腺癌需要依赖β-catenin活动.pdfVIP

CK1e Is Required for Breast Cancers Dependent on b- Catenin Activity 1,4,5,6. 1,2,6. 1,3,5,6 6 1 So Young Kim , Ian F. Dunn , Ron Firestein , Piyush Gupta , Leslie Wardwell , Kara 1,6 1,4,5,6 7,8 6 6 5,6 Repich , Anna C. Schinzel , Ben Wittner , Serena J. Silver , David E. Root , Jesse S. Boehm , 6,7,8,9 6 1,4,5,6 Sridhar Ramaswamy , Eric S. Lander , William C. Hahn * 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 2 Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 5 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 6 Broad Institute, Cambridge, Massachusetts, United States of America, 7 Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America, 8 Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 9 Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America Abstract Background: Aberrant b-catenin signaling plays a key role in several can