characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates描述的全基因组协会上位信号在人类血清尿酸隔离.pdfVIP

Characterisation of Genome-Wide Association Epistasis Signals for Serum Uric Acid in Human Population Isolates 1 2 3 1 1 Wenhua Wei *, Gibran Hemani , Andrew A. Hicks , Veronique Vitart , Claudia Cabrera-Cardenas , Pau 1 1 1 4 5,6 3,7,8 Navarro , Jennifer Huffman , Caroline Hayward , Sara A. Knott , Igor Rudan , Peter P. Pramstaller , 5 5 5 1 1 Sarah H. Wild , James F. Wilson , Harry Campbell , Malcolm G. Dunlop , Nicholas Hastie , Alan F. Wright1, Chris S. Haley1,2* 1 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom, 2 The Roslin Institute and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom, 3 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated ¨ ¨ Institute of the University of Lubeck, Lubeck, Germany, 4 Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom, 5 Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom, 6 Croatian Centre for Global Health, University of Split, Split, Croatia, 7 Department of Neurology, ¨ ¨ General Central Hospital, Bolzano, Italy, 8 Department of Neurology, University of Lubeck, Lubeck, Germany Abstract Genome-wide association (GWA) studies have identified