cpg island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cellscpg岛甲基化在淋巴瘤小鼠模型是由肿瘤细胞的基因结构.pdfVIP

CpG Island Methylation in a Mouse Model of Lymphoma Is Driven by the Genetic Configuration of Tumor Cells 1,2,3[ 1,2,3,4[ 1,2,3 1,2¤ 1,2,3 Rene Opavsky , Shu-Huei Wang , Prashant Trikha , Aparna Raval , Yuan Huang , Yue-Zhong Wu1,2,4, Benjamin Rodriguez1,2,3, Benjamin Keller1,2,3, Sandya Liyanarachchi1,2, Guo Wei1,2,3,5, Ramana V. Davuluri1,2 1,2,3 6 1,2,3,5 1,2,3* , Michael Weinstein , Dean Felsher , Michael Ostrowski , Gustavo Leone , Christoph Plass1,2,4* 1 Human Cancer Genetics Program, Department of Molecul\ar Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America, 2 Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, 3 Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America, 4 Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America, 5 Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America, 6 Department of Medicine, Stanford University, Stanford, California, United States of America Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer. Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological significance and the underlying mechanisms of tumor-specific aberrant promoter methylation remain unclear, but some evidence suggests that this specificity involves differential sequence susceptibilities, the targeting of DNA me