crohns disease and early exposure to domestic refrigeration克罗恩氏病和早期暴露在国内制冷.pdfVIP

Crohn’s Disease and Early Exposure to Domestic Refrigeration 1 2,3 1 1 2,3 Fatemeh Malekzadeh , Corinne Alberti , Mehdi Nouraei , Homayoon Vahedi , Isabelle Zaccaria , 4,5,6 1 1 1 Ulrich Meinzer , Siavosh Nasseri-Moghaddam , Rasoul Sotoudehmanesh , Sara Momenzadeh , Reza 1 1 1 1 4,5,6 Khaleghnejad , Shahrooz Rashtak , Golrokh Olfati , Reza Malekzadeh , Jean-Pierre Hugot * ´ ´ ´ ˆ ´ 1 Digestive Disease Research Center, Medical Sciences, University of Tehran, Tehran, Iran, 2 APHP, Unite d’epidemiologie clinique, Hopital Robert Debre, Paris, France, ´ ´ ˆ ´ ´ 3 INSERM CIE5, Paris, France, 4 AP-HP, service de gastroenterologie pediatrique, Hopital Robert Debre, Paris, France, 5 Universite Paris Diderot, Paris, France, 6 INSERM U843, Paris, France Abstract Background: Environmental risk factors playing a causative role in Crohn’s Disease (CD) remain largely unknown. Recently, it has been suggested that refrigerated food could be involved in disease development. We thus conducted a pilot case control study to explore the association of CD with the exposure to domestic ref