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Cross Border Comparison of MRSA Bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): A Cross-Sectional Study 1,2 2,3 1 1 Brigitte A. G. L. van Cleef *, Jan A. J. W. Kluytmans , Birgit H. B. van Benthem , Anja Haenen , 1 4 4 5 Jos Monen , Inka Daniels-Haardt , Annette Jurke , Alexander W. Friedrich 1 Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and The Environment, Bilthoven, The Netherlands, 2 Department of Medical Microbiology and Infection Prevention, VU University Medical Centre, Amsterdam, The Netherlands, 3 Laboratory for Microbiology and Infection Control, Amphia Hospital, ¨ Breda, The Netherlands, 4 North Rhine-Westphalian Center for Health, Munster, Germany, 5 Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Background: We describe the impact of methicillin-resistant Staphylococcus aureus (MRSA) in two neighbouring regions in Europe with a comparable population size, North Rhine-Westphalia (NRW) in Germany and the Netherlands. Methodology/Principal Findings: We compared the occurrence of MRSA in blood cultures from surveillance systems. In the Netherlands in 2009, 14 of 1,510 (0.9%) Staphylococcus aureus bacteraemia episodes under surveillance were MRSA. Extrapolation using the number of clinical admissions results in a total of 29 MRSA bacteraemia episodes in the Netherlands or 1.8 episodes per 1,000,000 inhabitants. In 2010 in NRW, 1,029 MRSA ba