cross-reactive neuraminidase antibodies afford partial protection against h5n1 in mice and are present in unexposed humans可交叉反应的神经氨酸酶抗体负担部分防止h5n1病毒在小鼠和存在于正常人类.pdfVIP

PLoS MEDICINE Cross-Reactive Neuraminidase Antibodies Afford Partial Protection against H5N1 in Mice and Are Present in Unexposed Humans 1 2 1 2 3 Matthew R. Sandbulte , Gretchen S. Jimenez , Adrianus C. M. Boon , Larry R. Smith , John J. Treanor , 1* Richard J. Webby 1 Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, 2 Vical, San Diego, California, United States of America, 3 Infectious Diseases Unit, University of Rochester, Rochester, New York, United States of America Funding: The studies were funded A B S T R A C T by a research grant from the National Institute of Allergy and Infectious Diseases and by the American Lebanese Syrian Background Associated Charities (ALSAC). The funders had no role in study design, A pandemic H5N1 influenza outbreak would be facilitated by an absence of immunity to the data collection and analysis, decision avian-derived virus in the human population. Although this condition is likely in regard to to publish, or preparation of the hemagglutinin-mediated immunity, the neuraminidase (NA) of H5N1 viruses (avN1) and of manuscript. endemic human H1N1 viruses (huN1) are classified in the same serotype. We hypothesized that Competing Interests: See section at an immune response to huN1 could mediate cross-protection a