原创力文档cross-reactivity of anthrax and c2 toxin protective antigen promotes the uptake of botulinum c2i toxin into human endothelial cells大的炭疽和c2肉毒毒素保护性抗原的吸收促进c2i毒素对人类内皮细胞.pdfVIP
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cross-reactivity of anthrax and c2 toxin protective antigen promotes the uptake of botulinum c2i toxin into human endothelial cells大的炭疽和c2肉毒毒素保护性抗原的吸收促进c2i毒素对人类内皮细胞
Cross-Reactivity of Anthrax and C2 Toxin: Protective
Antigen Promotes the Uptake of Botulinum C2I Toxin
into Human Endothelial Cells
1. 2,3. 1 2 1
Angelika Kronhardt , Monica Rolando , Christoph Beitzinger , Caroline Stefani , Michael Leuber ,
2 4 1,5 2,3,6
Gilles Flatau , Michel R. Popoff , Roland Benz *, Emmanuel Lemichez *
¨ ¨ ˆ `
1 Rudolf-Virchow-Center, University of Wurzburg, Wurzburg, Germany, 2 Inserm, U895, Toxines Microbiennes dans la Relation Hote-Pathogenes, Batiment Archimed, Nice,
´ ´ ´ ´ ´ ´ ´
France, 3 Faculte de Medecine, Institut Federatif de Recherche 50, Universite de Nice-Sophia Antipolis, Nice, France, 4 Unite des Bacteries Anaerobies et Toxines, Institut
´
Pasteur, Paris, France, 5 School of Engineering and Science, Jacobs University Bremen, Bremen, Germany, 6 Laboratoire central de bacteriologie, Centre Hospitalier
Universitaire de Nice, Nice, France
Abstract
Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and
exhibit fatal enzymatic activities in eukaryotic cells. Anthrax and C2 toxin are the most prominent examples for the AB7/8
type of toxins. The B subunits bind bot
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