cyp26b1 regulates retinoic acid-dependent signals in t cells and its expression is inhibited by transforming growth factor-βcyp26b1调节视黄acid-dependent信号抑制了t细胞及其表达式转换factor-β增长.pdfVIP

Cyp26b1 Regulates Retinoic Acid-Dependent Signals in T Cells and Its Expression Is Inhibited by Transforming Growth Factor-b Hajime Takeuchi1,2*, Aya Yokota1,2, Yoshiharu Ohoka1,2, Makoto Iwata1,2* 1 Laboratory of Biodefense Research, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Japan, 2 Japan Science and Technology Agency, CREST, Tokyo, Japan Abstract Background: The vitamin A metabolite, retinoic acid (RA), plays important roles in the regulation of lymphocyte properties. Dendritic cells in gut-related lymphoid orga