correcting the site frequency spectrum for divergence-based ascertainment纠正网站频谱divergence-based确定.pdfVIP

Correcting the Site Frequency Spectrum for Divergence- Based Ascertainment Andrew D. Kern* Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America Abstract Comparative genomics based on sequenced referenced genomes is essential to hypothesis generation and testing within population genetics. However, selection of candidate regions for further study on the basis of elevated or depressed divergence between species leads to a divergence-based ascertainment bias in the site frequency spectrum within selected