原创力文档dc-sign (cd209) promoter ？336 ag polymorphism is associated with dengue hemorrhagic fever and correlated to dc-sign expression and immune augmentationdc-sign(cd209)启动子 336 ag)多态性与登革出血热相关联和相关dc-sign表达和免疫增强.pdfVIP
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dc-sign (cd209) promoter ？336 ag polymorphism is associated with dengue hemorrhagic fever and correlated to dc-sign expression and immune augmentationdc-sign(cd209)启动子 336 ag)多态性与登革出血热相关联和相关dc-sign表达和免疫增强
DC-SIGN (CD209) Promoter 2336 A/G Polymorphism Is
Associated with Dengue Hemorrhagic Fever and
Correlated to DC-SIGN Expression and Immune
Augmentation
1,5. 2. 3 3 2 1,5
Lin Wang , Rong-Fu Chen , Jien-Wei Liu , Ing-Kit Lee , Chiu-Ping Lee , Ho-Chang Kuo , Shau-Ku
Huang4, Kuender D. Yang1,2,5*
1 Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center (CGMH-KMC), Kaohsiung, Taiwan, 2 Department of Medical Research, CGMH-KMC,
Kaohsiung, Taiwan, 3 Division of Infectious Diseases, Department of Internal Medicine, CGMH-KMC, Kaohsiung, Taiwan, 4 Johns Hopkins Asthma and Allergy Center,
Baltimore, Maryland, United States of America, 5 Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Abstract
Background: The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a
single nucleotide polymorphism (SNP) in the promoter region of CD209 (2336 A/G; rs4804803) is susceptible to many
infectious diseases. We reason that variations in the DC-SIGN gene might have a broad influence on viral replication and
host immune responses.
Methods and Findings: We studied whether the rs4804803 SNP was associated with a susceptibility to dengue fever (DF)
and/or dengue hemorrhagic fever (DHF) through genotyping analysis in a Taiwanese cohort. We generated monocyte-
derived dendritic cells (MDDCs) from individuals with AA or AG genotype of rs4804803 to study the viral replication and
immune responses for functional validation. A total of 574 DNA samples were genotyped, including 176 DF, 135 DHF, 143
other non-dengue febrile illnesses (OFI) and 120 population controls. A strong ass
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