defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus有缺陷的夜间觉醒反应在1型糖尿病患者低血糖.pdfVIP

PLoS MEDICINE Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus 1* 1 2 2 1 1 Bernd Schultes , Kamila Jauch-Chara , Steffen Gais , Manfred Hallschmid , Eva Reiprich , Werner Kern , 3 1 1 2 Kerstin M. Oltmanns , Achim Peters , Horst L. Fehm , Jan Born 1 Department of Internal Medicine, University of Luebeck, Luebeck, Germany, 2 Department of Neuroendocrinology, University of Luebeck, Luebeck, Germany, 3 Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany Funding: The study was funded by a A B S T R A C T grant from the Deutsche Forschungsgemeinschaft (SFB 654: Plasticity and Sleep). The funders had no role in study design, data Background collection and analysis, decision to publish, or preparation of the Nocturnal hypoglycemia frequently occurs in patients with type 1 diabetes mellitus (T1DM). manuscript. It can be fatal and is believed to promote the development of the hypoglycemia-unawareness Competing Interests: The authors syndrome. Whether hypoglycemia normally provokes awakening from sleep in individuals who have declared that no competing do not have diabetes, and whether this awakening response is impaired in T1DM patients, is interests exist. unknown. Academic Editor: Leif C. Groop, Lund University Hospital, Sweden Methods and Findings Citation: Schultes B, Jauch-Chara K, Gais S, Hallschmid M, Reiprich E, et We tested two groups of 16 T1DM patients and 16 healthy control participants, respective