dengue virus activates polyreactive, natural igg b cells after primary and secondary infection登革病毒激活polyreactive,自然中小学感染后免疫球蛋白g b细胞.pdfVIP

Dengue Virus Activates Polyreactive, Natural IgG B Cells after Primary and Secondary Infection 1. 2. 1 3 4 Thavamalar Balakrishnan , Dennis B. Bela-Ong , Ying Xiu Toh , Marie Flamand , Shamala Devi , 5,9 6 7 8 8 2 1 Mickey B. Koh , Martin L. Hibberd , Eng Eong Ooi , Jenny G. Low , Yee Sin Leo , Feng Gu , Katja Fink * 1 Singapore Immunology Network, Agency for Science, Technology and Research A*STAR, Singapore, Singapore, 2 Novartis Institute for Tropical Diseases, Singapore, Singapore, 3 Department of Virology, Institut Pasteur, Paris, France, 4 Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia, 5 Blood Services Group, Health Sciences Authority, Singapore General Hospital, Singapore, Singapore, 6 Genome Institute of Singapore, Agency for Science, Technology and Research A*STAR, Singapore, Singapore, 7 Duke-NUS Graduate Medical School, Singapore, Singapore, 8 Department of Infectious Diseases, Communicable Disease Centre, Tock Seng Hospital, Singapore, Singapore, 9 Department of Haematology, St George’s Hospital, London, United Kingdom Abstract Background: Dengue virus is transmitted by mosquitoes and has four serotypes. Cross-protection to other serotypes lasting for a few months is observed following infection with one serotype. There is evidence that low-affinity T and/or B cells from primary infections contribute to the severe syndromes often associated with secondary dengue infections. such pronounced immune-mediated enhancement suggests a dengu