原创力文档design principles for ligand-sensing, conformation-switching ribozymes设计原则为ligand-sensing conformation-switching核酶.pdfVIP
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design principles for ligand-sensing, conformation-switching ribozymes设计原则为ligand-sensing conformation-switching核酶
Design Principles for Ligand-Sensing, Conformation-
Switching Ribozymes
Xi Chen, Andrew D. Ellington*
Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, United States of America
Abstract
Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications. A number of
ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes) have been
generated by some combination of dir
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