cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic micecyclooxygenase-2抑制变弱腹主动脉瘤hyperlipidemic老鼠的进展.pdfVIP

Cyclooxygenase-2 Inhibition Attenuates Abdominal Aortic Aneurysm Progression in Hyperlipidemic Mice Sarbani Ghoshal, Charles D. Loftin* Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America Abstract Abdominal aortic aneurysms (AAAs) are a chronic inflammatory disease that increase the risk of life-threatening aortic rupture. In humans, AAAs have been characterized by increased expression of cyclooxygenase-2 and the inactivation of COX-2 prior to disease initiation redu