copying and evolution of neuronal topology复制和神经元拓扑结构的演变.pdfVIP

Copying and Evolution of Neuronal Topology 1,2 1 ¨ ´ 2,3,4 Chrisantha Fernando *, K. K. Karishma , Eors Szathmary 1 MRC National Institute for Medical Research, Mill Hill, London, United Kingdom, 2 Collegium Budapest (Institute for Advanced Study), Budapest, Hungary, 3 Parmenides ¨ ¨ Foundation, Munich, Germany, 4 Institute of Biology, Eotvos University, Budapest, Hungary Abstract We propose a mechanism for copying of neuronal networks that is of considerable interest for neuroscience for it suggests a neuronal basis for causal inference, function copying, and natural selection within the human brain. To date, no model of neuronal topology copying exists. We present three increasingly sophisticated mechanisms to demonstrate how topographic map formation coupled with Spike-Time Dependent Plasticity (STDP) can copy neuronal topology motifs. Fidelity is improved by error correction and activity-reverberation limitation. The high-fidelity topology-copying operator is used to evolve neuronal topologies. Possible roles for neuronal natural selection are discussed. ´ Citation: Fernando C, Karishma KK, Szathmary E (2008) Copying and Evolution of Neuronal Topology. PLoS ONE 3(11): e3775. doi:10.1371/journal.pone.0003775 Editor: Aldo Rustichini, University of Minnesota, United States of America Received June 16, 2008; Accepted November 2, 2008; Published November 20, 2008 Copyright: 2008 Fernando et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original