comparative genomics of multidrug resistance in acinetobacter baumannii比较基因组学的多药耐药性鲍曼不动杆菌.pdfVIP

Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii 1¤* 2 ´ 2 ´ 1 1 3 Pierre-Edouard Fournier , David Vallenet , Valerie Barbe , Stephane Audic , Hiroyuki Ogata , Laurent Poirel , ´ 4 4 2 1 3 2 Herve Richet , Catherine Robert , Sophie Mangenot , Chantal Abergel , Patrice Nordmann , Jean Weissenbach , 4 1* Didier Raoult , Jean-Michel Claverie ´ ´ ´ 1 Information Genomique et Structurale, Institute for Structural Biology and Microbiology, IBSM, Marseille, France, 2 Genoscope, Centre National de Sequenc¸age and CNRS ´ ´ ˆ ˆ ˆ ´ ´ UMR8030, Evry, France, 3 Departement de Bacteriologie-Virologie, Hopital de Bicetre, Le-Kremlin-Bicetre, France, 4 Unite des Rickettsies, CNRS UMR6020, Faculte de ´ ´ ´ ´ Medecine, Universite de la Mediterranee, Marseille, France Acinetobacter baumannii is a species of nonfermentative gram-negative bacteria commonly found in water and soil. This organism was susceptible to most antibiotics in the 1970s. It has now become a major cause of hospital-acquired infections worldwide due to its remarkable propensity to rapidly acquire resistance determinants to a wide range of antibacterial agents. Here we use a comparative genomic approach to identify the complete repertoire of resistance genes exhibited by the multidrug-resistant A