circulating cd62e+ microparticles and cardiovascular outcomes循环cd62e +微粒子和心血管的结果.pdfVIP

Circulating CD62E+ Microparticles and Cardiovascular Outcomes 1,2. 1,2. 1,2 1 1 1 Soon-Tae Lee , Kon Chu , Keun-Hwa Jung , Jeong-Min Kim , Hye-Jin Moon , Jae-Jun Bahn , Woo- 1 1 1 1,2 1,2 1,2 Seok Im , Junsang Sunwoo , Jangsup Moon , Manho Kim , Sang Kun Lee , Jae-Kyu Roh * 1 Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea, 2 Program in Neuroscience, Neuroscience Research Institute of Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea Abstract Background: Activated endothelial cells release plasma membrane submicron vesicles expressing CD62E (E-selectin) into blood, known as endothelial microparticles (EMPs). We studied whether the levels of endothelial microparticles expressing CD62E+ + + + 2 , CD31 /Annexin-V , or CD31 /CD42 predict cardiovascular outcomes in patients with stroke history. Methods/Principal Findings: Patients with stroke history at least 3 months prior to enrolment were recruited. Peripheral blood EMP levels were measured by flow cytometry. Major cardiovascular events and death were monitored for 36 months. Three hundred patients were enrolled, of which 298 completed the study according to protocol. Major cardiovascular events occurred in 29 patients (9.7%). Nine patients died, five from cardiovascular causes. Cumulative event-free survival rates were lower in patients with high