changes in waist circumference and the incidence of acute myocardial infarction in middle-aged men and women腰围的变化和急性心肌梗死的发生率在中年男性和女性.pdfVIP

Changes in Waist Circumference and the Incidence of Acute Myocardial Infarction in Middle-Aged Men and Women 1 2 3 4 Tina Landsvig Berentzen *, Marianne Uhre Jakobsen , Jakob Gerhard Stegger , Jytte Halkjaer , Anne 4 1 2,3 Tjønneland , Thorkild I. A. Sørensen , Kim Overvad 1 Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark, 2 Department of Epidemiology, School of Public Health, Aarhus University Aarhus, Denmark, 3 Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, 4 The Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark Abstract Background: Waist circumference (WC) measured at one point in time is positively associated with the risk of acute myocardial infarction (MI), but the association with changes in WC (DWC) is not clear. We investigated the association between DWC and the risk of MI in middle-aged men and women, and evaluated the influence from concurrent changes in BMI (DBMI). Methodology/Principal Findings: Data on 38,593 participants from the Danish Diet, Cancer and Health study was analysed. Anthropometry was assessed in 1993–97 and 1999–02. Information on fatal and non-fatal MI was obtained from National Registers. Cases were validated by review of the medical records. Hazard ratios (HR) were calculated from Cox proportional hazard models with individuals considered at risk from 1999–02 until December 30 2009. During 8.4 years of follow-up, 1,041 incident cases of MI occurred. WC was positively associated with the risk of MI, but weakly after adjustment for BMI. DWC was not associated with th