capnography for assessing nocturnal hypoventilation and predicting compliance with subsequent noninvasive ventilation in patients with alscapnography评估夜间肺换气不足和预测符合后续als患者无创通气.pdfVIP

Capnography for Assessing Nocturnal Hypoventilation and Predicting Compliance with Subsequent Noninvasive Ventilation in Patients with ALS 1,2 1,2 3 4 5 1 Sung-Min Kim , Kyung Seok Park , Hyunwoo Nam , Suk-Won Ahn , Suhyun Kim , Jung-Joon Sung *, Kwang-Woo Lee1* 1 Department of Neurology, Seoul National University College of Medicine, Seoul, Korea, 2 Department of Neurology, Seoul National University, Bundang Hospital, Gyeonggi, Korea, 3 Department of Neurology, Boramae Hospital, Seoul, Korea, 4 Department of Neurology, Chung-Ang University Hospital, Seoul, Korea, 5 Department of Neurology, National Cancer Center, Gyeonggi, Korea Abstract Background: Patients with amyotrophic lateral sclerosis (ALS) suffer from hypoventilation, which can easily worsen during sleep. This study evaluated the efficacy of capnography monitoring in patients with ALS for assessing nocturnal hypoventilation and predicting good compliance with subsequent noninvasive ventilation (NIV) treatment. Methods: Nocturnal monitoring and brief wake screening by capnography/pulse oximetry, functional scores, and other respiratory signs were assessed in 26 patients with ALS. Twenty-one of these patients were treated with NIV and had their treatment compliance evaluated. Results: Nocturnal capnography values were reliable and strongly correlated with the patients’ respiratory symptoms (R2 = 0.211–0.305, p = 0.004–0.021). The duration of nocturnal hypercapnea obtained by capnography exhibited a significant predictive power for good compliance with subsequent NIV treatment, with an area-under-the-curve value of 0.846 (p = 0.018). In contrast, no significant pr