bradykinin β2 receptor ？58tc gene polymorphism and essential hypertension a meta-analysis缓激肽受体β2 58 tc基因多态性与原发性高血压的荟萃分析.pdfVIP

Bradykinin b2 Receptor 258T/C Gene Polymorphism and Essential Hypertension: A Meta-Analysis 1 2 1 1 2 1 1 Yan-yan Li *, Hui Zhang , Jian Xu , Yun Qian , Xin-zheng Lu , Bing Yang , Minglong Chen , Zhi- 1,2 2 jian Yang , Ke-jiang Cao * 1 Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2 Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Abstract Background: Research has shown that bradykinin b2 receptor (BDKRB2) 258T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive. Objective and Methods: The objective of this study was to explore the association between BDKRB2 258T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2 258T/C gene polymorphism and EH and their corresponding 95% confidence intervals (CIs) were estimated using the random effects model. Results: The BDKRB2 258T/C gene polymorphism was significantly correlated with EH under an allelic genetic model (OR = 1.24, 95% CI = 1.05–1.46; P = 0.01), a dominant genetic model (OR = 0.65, 95% CI = 0.47–0.90; P = 0.01), a recessive genetic model (OR = 1.146, 95% CI = 1.035–1.269; P = 0.009), a homozygote genetic model (OR = 1.134, 95% CI = 1.048–1.228; P = 0.002), and a heterozygote genetic model (OR = 1.060, 95% CI = 1.009–1.112; P = 0.019). Conclusions: The BDKRB2 258T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the 258C allele are susceptible to EH. Citati