capacity-speed relationships in prefrontal cortex在前额叶皮层capacity-speed关系.pdfVIP

Capacity-Speed Relationships in Prefrontal Cortex 1,2,3 4 5 2 Vivek Prabhakaran *, Bart Rypma , Nandakumar S. Narayanan , Timothy B. Meier , Benjamin P. 6 1 3 7 8 Austin , Veena A. Nair , Lin Naing , Lisa E. Thomas , John D. E. Gabrieli 1 Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 4 Center for Brain Health, University of Texas-Dallas, Dallas, Texas, United States of America, 5 Department of Neurology, Yale University, New Haven, Connecticut, United States of America, 6 Cardiovascular Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 7 Departments of Emergency Medicine, Brigham Women’s Hospital and Massachusetts General Hospital, Boston, Massachusetts, United States of America, 8 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America Abstract Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in ca