changes in the nasal colonization with methicillin-resistant staphylococcus aureus in children 2004-2009改变鼻殖民与儿童耐甲氧西林金黄色葡萄球菌2004 - 2009.pdfVIP

Changes in the Nasal Colonization with Methicillin- Resistant Staphylococcus aureus in Children: 2004-2009 1 1 1 2 1 Wen-Tsung Lo *, Chih-Chien Wang , Wei-Jen Lin , Sheng-Ru Wang , Ching-Shen Teng , Ching-Feng Huang1, Shyi-Jou Chen1 1 Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 2 Department of Pediatrics, Wan Fang Hospital, Taipei, Taiwan Abstract Background: Staphylococcus aureus is an important cause of infection, particularly in persons colonized with this organism. This study compared the annual prevalence and microbiological characteristics of methicillin-resistant S. aureus (MRSA) nasal colonization in Taiwanese children from 2004 through 2009. Risk factors for MRSA were determined for the overall study period. Methods: Children from birth to #14 years of age presenting for health maintenance visits or attending 1 of 57 kindergartens were recruited. Nasal swabs were obtained, and a questionnaire was administered. The prevalence and microbiological characteristics of MRSA colonization were also calculated for two 3-year periods: 2004–2006 and 2007–2009. Results: Cultures of the anterior nares were positive for S. aureus in 824 (25.8%) of the 3,200 children, and MRSA colonization was found in 371 (11.6%) children. The prevalence of S. aureus colonization decreased from 28.1% in 2004– 2006 to 23.3% in 2007–2009 (p ,0.01), whereas the prevalence of MRSA colonization increased from 8.1% to 15.1% during this period (p ,0.0001). Multivariate analysis revealed that the independent risk factors for MRSA carriage were different for male and female children, and also among age groups. Most MRSA isolates