circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health data from the baltimore longitudinal study of aging循环脑源性神经营养因子和代谢和心血管健康数据的指数从巴尔的摩衰老的纵向研究.pdfVIP

Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic and Cardiovascular Health: Data from the Baltimore Longitudinal Study of Aging 1. 2. 3 4 5 Erin Golden , Ana Emiliano , Stuart Maudsley , B. Gwen Windham , Olga D. Carlson , Josephine M. 5 6 4 2 1 Egan , Ira Driscoll , Luigi Ferrucci , Bronwen Martin *, Mark P. Mattson 1 Cellular and Molecular Neurosciences Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 2 Metabolism Unit, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 3 Receptor Pharmacology Unit, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 4 Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 5 Diabetes Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 6 Laboratory of Personality and Cognition, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America Abstract Background: Besides its well-established role in nerve cell survival and adaptive plasticity, brain-derived neurotrophic factor (BDNF) is also involved in energy homeostasis and cardiovascular regulation. Although BDNF is present in the systemic circulation, it is unknown whether plasma BDNF correlates with circulating markers of dysregulated metabolism and an adverse cardiovascular profile. Methodology/Principal Findings: To det