circulating and pbmc lp-pla2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status)循环和pbmc lp-pla2将以不同的方式与氧化应激和亚临床炎症nonobese妇女(更年期状态).pdfVIP

Circulating and PBMC Lp-PLA2 Associate Differently with Oxidative Stress and Subclinical Inflammation in Nonobese Women (Menopausal Status) 1,2. 1,2. 1,2 2 3 4 Jean Kyung Paik , Ji Young Kim , Oh Yoen Kim , Yonghee Lee , Tae-Sook Jeong , Gary Sweeney , Yangsoo Jang1,5,6,7, Jong Ho Lee1,2* 1 Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea, 2 National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea, 3 National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 4 Institut Pasteur Korea, Seoul, Korea Department of Biology, York University, Toronto, Canada, 5 Cardiology Division, Yonsei University College of Medicine, Seoul, Korea, 6 Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea, 7 Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea Abstract Background: This study aimed to determine the association of lipoprotein-associated phospholipase A (Lp-PLA ) activity in 2 2 circulation and peripheral blood mononuclear cells (PBMCs) with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA2 activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. Methodology/Principal Findings: Eighty postmenopausal