changes in the treatment responses to artesunate-mefloquine on the northwestern border of thailand during 13 years of continuous deployment治疗反应的变化artesunate-mefloquine西北边境的泰国在13年的持续部署.pdfVIP

Changes in the Treatment Responses to Artesunate- Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment 1 1 1,2,3 3,4 2,3 Verena Ilona Carrara , Julien Zwang , Elizabeth A Ashley , Ric N Price , Kasia Stepniewska , Marion 1 4 5 1,2,3 1 1 Barends , Alan Brockman , Tim Anderson , Rose McGready , Lucy Phaiphun , Stephane Proux , 1 1 1 1 Michele van Vugt , Robert Hutagalung , Khin Maung Lwin , Aung Pyae Phyo , Piyanuch 2 2 2 2 Preechapornkul , Mallika Imwong , Sasithon Pukrittayakamee , Pratap Singhasivanon , Nicholas J. White2,3, Franc¸ois Nosten1,2,3* 1 Shoklo Malaria Research Unit, Tak, Thailand, 2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3 Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom, 4 Menzies School of Health Research, Charles Darwin University, Darwin, Australia, 5 Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America Abstract Background: Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world. We reviewed the efficacy of a 3-day regimen of mefloquine and artesunate regimen (MAS3), over a 13 year period of continuous deployme