comparative ice genomics insights into the evolution of the sxtr391 family of ices冰比较基因组学见解的演变sxtr391冰的家庭.pdfVIP

Comparative ICE Genomics: Insights into the Evolution of the SXT/R391 Family of ICEs 1,2,3 3 4 4 Rachel A. F. Wozniak , Derrick E. Fouts , Matteo Spagnoletti , Mauro M. Colombo , Daniela 5 ` 5 ´ 5 5 1,2,6 Ceccarelli , Genevieve Garriss , Christine Dery , Vincent Burrus *, Matthew K. Waldor * 1 Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Genetics, Tufts Medical School, Boston, Massachusetts, United States of America, 3 J. Craig Venter Institute, Rockville, Maryland, United States of America, 4 Dipartimento di Biologia ´ ´ ´ ´ Cellulare e dello Sviluppo, Universita di Roma La Sapienza, Rome, Italy, 5 Centre d’Etude et de Valorisation de la Diversite Microbienne, Departement de Biologie, ´ ´ Universite de Sherbrooke, Sherbrooke, Quebec, Canada, 6 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America Abstract Integrating and conjugative elements (ICEs) are one of the three principal types of self-transmissible mobile genetic elements in bacteria. ICEs, like plasmids, transfer via conjugation; but unlike plasmids and similar to many phages, these elements integrate into and replicate along with the host chromosome. Members of the SXT/R391 family