circulating micro-rnas as potential blood-based markers for early stage breast cancer detection循环微- rnas作为潜在blood-based标记为早期乳腺癌检测.pdfVIP

Circulating Micro-RNAs as Potential Blood-Based Markers for Early Stage Breast Cancer Detection 1,2 . 1,2. ¨ 3 1,2 Michael G. Schrauder * , Reiner Strick , Rudiger Schulz-Wendtland , Pamela L. Strissel , Laura 1,2 1,2 1,2 1,2 4 Kahmann , Christian R. Loehberg , Michael P. Lux , Sebastian M. Jud , Arndt Hartmann , 1,2 1,2 1,2 1,2 3 Alexander Hein , Christian M. Bayer , Mayada R. Bani , Swetlana Richter , Boris R. Adamietz , Evelyn Wenkel3, Claudia Rauh1,2, Matthias W. Beckmann1,2, Peter A. Fasching1,2,5 1 Department of Obstetrics and Gynaecology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, 2 Comprehensive Cancer Center Erlangen-Nuremberg, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, 3 Institute of Diagnostic Radiology, University Hospital Erlangen, Erlangen, Germany, 4 Institute of Pathology, University Hospital Erlangen, Erlangen, Germany, 5 Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Abstract Introduction: MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators of gene expression thereby affecting crucial processes in cancer development. MiRNAs offer great potential as biomarkers for cancer