chaotic signatures of heart rate variability and its power spectrum in health, aging and heart failure心率变异性的混沌特征及其功率谱在健康、衰老和心脏衰竭.pdfVIP

Chaotic Signatures of Heart Rate Variability and Its Power Spectrum in Health, Aging and Heart Failure 1 2,3 4 5 5 6 Guo-Qiang Wu , Natalia M. Arzeno , Lin-Lin Shen , Da-Kan Tang , Da-An Zheng , Nai-Qing Zhao , 7 2 Dwain L. Eckberg , Chi-Sang Poon * 1 Department of Mechanics and Engineering Science, Fudan University, Shanghai, People’s Republic of China, 2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 4 Department of Physiology and Pathophysiology, Fudan University, Shanghai, People’s Republic of China, 5 School of Information Science and Engineering, Fudan University, Shanghai, People’s Republic of China, 6 School of Public Health, Fudan University, Shanghai, People’s Republic of China, 7 Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, United States of America Abstract A paradox regarding the classic power spectral analysis of heart rate variability (HRV) is whether the characteristic high- (HF) and low-frequency (LF) spectral peaks represent stochastic or chaotic phenomena. Resolution of this fundamental issue is key to unraveling the mechanisms of HRV, which is critical to its proper use as a noninvasive marker for cardiac mortality risk assessment and stratification in congestive heart failure (CHF) and other cardiac dysfunctions. However, conventional techniques of nonlinear time series analysis generally lack sufficient sensitivity, specificity and robustness