circulating micrornas in patients with shiga-toxin-producing e. coli o104h4 induced hemolytic uremic syndrome患者循环小分子核糖核酸shiga-toxin-producing o104h4大肠杆菌引起的溶血性尿毒症综合征.pdfVIP

Circulating microRNAs in Patients with Shiga-Toxin- Producing E. coli O104:H4 Induced Hemolytic Uremic Syndrome 1,2. 2. 2 1 1 Johan M. Lorenzen *, Jan Menne , Bernhard M.W. Schmidt , Mascha Schmidt , Filippo Martino , 1,2 1,2 3 3 3 Robert Dietrich , Senguel Samiri , Hans Worthmann , Meike Heeren , Karin Weissenborn , 2 2 2 1,4 Hermann Haller , Mario Schiffer , Jan T. Kielstein , Thomas Thum * 1 Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover, Germany, 2 Division of Nephrology and Hypertension, Department of Medicine, Hanover Medical School, Hannover, Germany, 3 Department of Neurology, Hanover Medical School, Hannover, Germany, 4 Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy Abstract Background: In early May 2011, an outbreak of hemorrhagic colitis associated with hemolytic–uremic syndrome (HUS) first developed in Northern Germany and spread to 15 other countries in Europe. The outbreak-strain O104:H4, which combined virulence factors of typical enteroaggregative and Shiga-Toxin–producing E. coli was associated with an unusual high rate of hemolytic uremic syndrome. Also an unexpected high rate of coma and seizures leading to mechanical ventilation and ICU treatment was observed. MicroRNAs are small ribonucleotides orchestrating gene expression. We tested whether circulating microRNAs in serum of HUS patients during the 2011 epidemics are altered in this patient c