circulating matrix metalloproteinase-9 is associated with cardiovascular risk factors in a middle-aged normal population循环矩阵metalloproteinase-9与中年正常人群心血管疾病的风险因素.pdfVIP

Circulating Matrix Metalloproteinase-9 Is Associated with Cardiovascular Risk Factors in a Middle-Aged Normal Population 1 2 3 2 1 Peter Garvin *, Lennart Nilsson , John Carstensen , Lena Jonasson , Margareta Kristenson ¨ ¨ 1 Division of Community Medicine, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden, 2 Division of Cardiology, Department of Medical ¨ ¨ ¨ and Health Sciences, Linkoping University, Linkoping, Sweden, 3 Division of Health and Society, Department of Medical and Health Sciences, Linkoping University, ¨ Linkoping, Sweden Abstract Background: Elevated levels of circulating matrix metalloproteinase-9 (MMP-9) have been demonstrated in patients with established coronary artery disease (CAD). The aim of this study was to analyse levels of MMP-9 in a population free from symptomatic CAD and investigate their associations with cardiovascular (CV) risk factors, including C-reactive protein (CRP). Methods: A cross-sectional study was performed in a population based random sample aged 45–69 (n = 345, 50% women). MMP-9 levels were measured in EDTA-plasma using an ELISA-method. CV risk factors were measured using questionnaires and standard laboratory methods. Results: Plasma MMP-9 was detectable in all participants, mean 38.9 ng/mL (SD 22.1 ng/mL). Among individuals without reported symptomatic CAD a positive association (p,0.001) was seen, for both men and women, of MMP-9 levels regarding total risk load of eight CV risk