circulating macc1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis循环macc1成绩单在结直肠癌患者血浆预测转移和预后.pdfVIP

Circulating MACC1 Transcripts in Colorectal Cancer Patient Plasma Predict Metastasis and Prognosis 1 2 1 1 1 Ulrike Stein *, Susen Burock , Pia Herrmann , Ina Wendler , Markus Niederstrasser , Klaus- Dieter Wernecke3, Peter M. Schlag 1,2 ´ ¨ ´ 1 Experimental and Clinical Research Center, Charite University Medicine Berlin, at the Max-Delbruck-Center for Molecular Medicine, Berlin, Germany, 2 Charite ´ Comprehensive Cancer Center, Berlin, Germany, 3 Institute of Medical Biometry, Charite University Medicine Berlin, Berlin, Germany Abstract Background: Metastasis is the most frequent cause of treatment failure and death in colorectal cancer. Early detection of tumors and metastases is crucial for improving treatment strategies and patient outcome. Development of reliable biomarkers and simple tests routinely applicable in the clinic for detection, prognostication, and therapy monitoring is of special interest. We recently identified the novel gene Metastasis-Associated in Colon Cancer 1 (MACC1), a key regulator of the HGF/Met-pathway. MACC1 is a strong prognostic biomarker for colon cancer metastasis and allows identification of high-risk subjects in early stages, when determined in patients’ primary tumors. To overcome the limitation of a restricted number of molecular analyses in tumor tissue, the establishment of a non-invasive blood test for early identification of high- risk cancer patients, for monitoring disease course and therapy response is s