circulating fibroblast growth factor 21 levels are closely associated with hepatic fat content a cross-sectional study21循环纤维母细胞生长因子水平与肝脏脂肪含量密切相关的横断面研究.pdfVIP

Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross- Sectional Study 1 1 1 1 1 2 2 Hongmei Yan , Mingfeng Xia , Xinxia Chang , Qiong Xu , Hua Bian , Mengsu Zeng , Shengxiang Rao , 2 3 3 1 Xiuzhong Yao , Yinfang Tu , Weiping Jia , Xin Gao * 1 Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China, 2 Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, 3 Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Abstract Background and Aims: Fibroblasts growth factor 21 (FGF21), a liver-secreted endocrine factor involved in regulating glucose and lipid metabolism, has been shown to be elevated in patients with non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the quantitative correlation between serum FGF21 level and hepatic fat content. Methods: A total of 138 subjects (72 male and 66 female) aged from 18 to 65 years with abnormal glucose metabolism and B-ultrasonography diagnosed fatty liver were enrolled in the study. Serum FGF21 levels were determined by an in-house chemiluminescence immunoassay and hepatic fat contents were measured by proton magnetic resonance spectroscopy. Results: Serum FGF21 increased progressively with the increase of hepatic fat content, but when hepatic fat content increased to the fourth quartile, FGF21 tended to decline. Serum FGF21 concentrations were positively correlated with