copy number variation of ccl3-like genes affects rate of progression to simian-aids in rhesus macaques (macaca mulatta)ccl3-like基因的拷贝数变异影响发展速度在恒河猴simian-aids(解剖).pdfVIP

Copy Number Variation of CCL3-like Genes Affects Rate of Progression to Simian-AIDS in Rhesus Macaques (Macaca mulatta) 1 2 2 2 2 Jeremiah D. Degenhardt , Paola de Candia , Adrien Chabot , Stuart Schwartz , Les Henderson , Binhua 3 3 4 5 5 4 Ling , Meredith Hunter , Zhaoshi Jiang , Robert E. Palermo , Michael Katze , Evan E. Eichler , Mario 6 7 3 2. 1. Ventura , Jeffrey Rogers , Preston Marx , Yoav Gilad *, Carlos D. Bustamante * 1 Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, 2 Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, 3 Tulane National Primate Research Center, Covington, Louisiana, United States of America, 4 Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, 5 Department of Microbiology, University of Washington, Seattle, Washington, United States of America, 6 Dipartimento di Genetica e Microbiologia, Universita’ degli Studi di Bari, Bari, Italy, 7 Department of Genetics, Southwest Foundation for Biomedical Research, and Southwest National Primate Research Center, San Antonio, Texas, United States of America Abstract Variation in genes underlying host immunity can lead to marked differences in susceptibility to HIV infection among humans. Despite heavy reliance on non-human primates as models for HIV/AIDS, little is known about which host factors are shared and which are unique to a given primate lineag