differential affinity and catalytic activity of chez in e. coli chemotaxis微分的亲和力和催化活性在大肠杆菌趋化作用.pdfVIP

Differential Affinity and Catalytic Activity of CheZ in E. coli Chemotaxis Siebe B. van Albada*, Pieter Rein ten Wolde FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands Abstract Push–pull networks, in which two antagonistic enzymes control the activity of a messenger protein, are ubiquitous in signal transduction pathways. A classical example is the chemotaxis system of the bacterium Escherichia coli, in which the kinase CheA and the phosphatase CheZ regulate the phosphorylation level of the messenger protein CheY. Recent experiments suggest