differential patterns of infection and disease with p. falciparum and p. vivax in young papua new guinean children微分的感染和疾病模式与恶性疟原虫和间日疟原虫在年轻的巴布新几内亚的孩子.pdfVIP

Differential Patterns of Infection and Disease with P. falciparum and P. vivax in Young Papua New Guinean Children 1 1 2 1 3,4 Enmoore Lin , Benson Kiniboro , Laurie Gray , Stuart Dobbie , Leanne Robinson , Annemarie 1 ¨ 5 1,3 1 2 1 Laumaea , Sonja Schopflin , Danielle Stanisic , Inoni Betuela , Melinda Blood-Zikursh , Peter Siba , 5 3 2 1 Ingrid Felger , Louis Schofield , Peter Zimmerman , Ivo Mueller * 1 PNG Institute of Medical Research, Madang, Papua New Guinea, 2 Centre for Global Health Disease, Case Western Reserve University, Cleveland, Ohio, United States of America, 3 Walter Eliza Hall Institute, Parkville, Victoria, Australia, 4 Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia, 5 Swiss Tropical Institute, Basel, Switzerland Abstract Background: Where P. vivax and P. falciparum occur in the same population, the peak burden of P. vivax infection and illness is often concentrated in younger age groups. Experiences from malaria therapy patients indicate that immunity is acquired faster to P. vivax than to P. falciparum challenge. There is however little prospective data on the comparative risk of infection and disease from both species in young children living in co-endemic areas. Methodology/Principal Findings: A cohort of 264 Papua New Guinean children aged 1-3 years (at enrolment) were actively followed-up for Plasmodium infection and febrile illness for 16 months. Infection statu