disruption of learned timing in pq calcium channel mutants中断pq钙通道突变体的学习时间.pdfVIP

Disruption of Learned Timing in P/Q Calcium Channel Mutants Akira Katoh, Peter J. Chapman, Jennifer L. Raymond* Department of Neurobiology, Stanford University, Stanford, California, United States of America Abstract To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning. Here we report that the modification of movement timing is highly dependent on signaling through P/Q- type voltage-dependent calcium channels. Two lines of mutant mice heterozygous for P/Q-type voltage-dependent calcium channels exhibited impaired plasticity of eye movement timing, but relatively intact plasticity of movement amplitude during motor learning in the vestibulo-ocular reflex. The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements. Citation: Katoh A, Chapman PJ, Raymond JL (2008) Disruption of Learned Timing in P/Q Calcium Channel Mutants. PLoS ONE 3(11): e3635. doi:10.1371/ journal.pone.0003635 Editor: Huibert D. Mansvelder, Vrije Universiteit Amsterdam, Netherlands Received May 12, 2008; Accepted October 2, 2008; Published November 4, 2008 Copyright: 2008 Katoh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This research was supported by an EJLB Foundation Award, James S. Mcdonnell Foundation 21st Century Research Award and NIH P01 NS0353862 to J.L.R.. A.K. was supported by a long-term fellowship from the Human Frontier Science Program. Competing Interests: The authors have declared that no competing interests exist. * E-mail: jenr@ Introduction