dissection of host cell signal transduction during acinetobacter baumannii – triggered inflammatory response解剖的宿主细胞信号转导在鲍曼不动杆菌,引发炎症反应.pdfVIP

Dissection of Host Cell Signal Transduction during Acinetobacter baumannii – Triggered Inflammatory Response 1,2 ´ 1,2 1,2 1,2 1,2 Catalina March , Veronica Regueiro , Enrique Llobet , David Moranta , Pau Morey , Junkal 1,2,3 ´ 1,2,4,5 Garmendia , Jose A Bengoechea * ´ ´ 1 Program Infection and Immunity, Fundacio Caubet-CIMERA Illes Balears, Bunyola, Spain, 2 Area Molecular Basis of Microbial Pathogenesis, Centro de Investigacion ´ ´ ´ ´ ´ Biomedica en Red Enfermedades Respiratorias, Bunyola, Spain, 3 Instituto de Agrobiotecnologıa, Pamplona, Spain, 4 Area de Microbiologıa, Facultad Biologıa, Universitat ´ Illes Balears, Palma Mallorca, Spain, 5 Consejo Superior de Investigaciones Cientıficas (CSIC), Madrid, Spain Abstract Infected airway epithelial cells up-regulate the expression of chemokines, chiefly IL-8, and antimicrobial molecules including b-defensins (BD). Acinetobacter baumannii is a cause of hospital-acquired pneumonia. We examined whether A. baumannii induced the expressions of IL-8 and BD2 by airway epithelial cells and the receptors implicated in bacterial detection. A549 and hu