differential infectivity by the oral route of trypanosoma cruzi lineages derived from y strain口服摄入的微分传染性鲁兹锥体血统来自y的压力.pdfVIP

Differential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain 1 1,2 1 1 1 Cristian Cortez , Rafael M. Martins , Renan M. Alves , Richard C. Silva , Luciana C. Bilches , 1 1,3 1,4 1 1 Silene Macedo , Vanessa D. Atayde , Silvia Y. Kawashita , Marcelo R. S. Briones , Nobuko Yoshida * ˜ ˜ ´ ˆ 1 Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2 Unite de Biologie des Interactions Hote-Parasite, ´ ˆ ´ ´ ´ ˜ Institut Pasteur, Paris, France, 3 McGill University Health Centre, Montreal, Quebec, Canada, 4 Superintendencia da Polıcia Tecnico-Cientıfica, Sao Paulo, Brazil Abstract Background: Diversity of T. cruzi strains is a central problem in Chagas disease research because of its correlation with the wide range of clinical manifestations and the biogeographical parasite distribution. The role played by parasite microdiversity in Chagas disease epidemiology is still debatable. Also awaits clarification whether such diversity is associated with the outcome of oral T. cruzi infection, responsible for frequent outbreaks of acute Chagas disease. Methods and