divergent cortical generators of meg and eeg during human sleep spindles suggested by distributed source modeling发散的皮质发电机梅格和脑电图在人类睡眠纺锤波提出的分布式源建模.pdfVIP

Divergent Cortical Generators of MEG and EEG during Human Sleep Spindles Suggested by Distributed Source Modeling 1,2,3 2,4 2,5 1 1 Nima Dehghani , Sydney S. Cash , Chih C. Chen , Donald J. Hagler Jr. , Mingxiong Huang , Anders M. Dale1,6, Eric Halgren1,6* 1 Department of Radiology, University of California San Diego, San Diego, California, United States of America, 2 Martinos Center for Biomedical Imaging, Harvard Medical ´ ´ School, Boston, Massachusetts, United States of America, 3 Laboratory for Computational Neuroscience, Unite de Neurosciences, Information et Complexite (UNIC), CNRS, Gif-sur-Yvette, France, 4 Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 5 Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, 6 Department of Neurosciences, University of California San Diego, San Diego, California, United States of America Abstract Background: Sleep spindles are ,1-second bursts of 10–15 Hz activity, occurring during normal stage 2 sleep. In animals, sleep spindles can be synchronous across multiple cortical and thalamic locations, suggesting a distributed stable phase- locked generating system. The high synchrony of spindles across scalp EEG sites suggests that this may also be true in humans. However, prior MEG studies suggest multiple and varying generators. Methodology/Principal Findings: We recorded 306 channels of MEG simultaneously with 60 channels of EEG during naturally occurring spindles of stage 2 sleep in 7 healthy subjects. High-reso