dynamic disorder in quasi-equilibrium enzymatic systems准平衡酶系统中动态障碍.pdfVIP

Dynamic Disorder in Quasi-Equilibrium Enzymatic Systems Srabanti Chaudhury, Oleg A. Igoshin* Department of Bioengineering, Rice University, Houston, Texas, United States of America Abstract Conformations and catalytic rates of enzymes fluctuate over a wide range of timescales. Despite these fluctuations, there exist some limiting cases in which the enzymatic catalytic rate follows the macroscopic rate equation such as the Michaelis- Menten law. In this paper we investigate the applicability of macroscopic rate laws for fluctuating enzyme systems in which catal