dynamic changes in ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes动态变化ezh2基因入住率是构成其参与对少突胶质细胞的神经干细胞自我更新和分化.pdfVIP

Dynamic Changes in Ezh2 Gene Occupancy Underlie Its Involvement in Neural Stem Cell Self-Renewal and Differentiation towards Oligodendrocytes Falak Sher, Erik Boddeke, Marta Olah, Sjef Copray* Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Background: The polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells. We previously demonstrated that Ezh2 is also expressed in m