dysbindin promotes the post-endocytic sorting of g protein-coupled receptors to lysosomes小促进g的post-endocytic排序protein-coupled受体溶酶体.pdfVIP

Dysbindin Promotes the Post-Endocytic Sorting of G Protein-Coupled Receptors to Lysosomes Aaron Marley, Mark von Zastrow* Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America Abstract Background: Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 dopamine receptors in neurons. Dysbindin is broadly expressed, and dopamine