early interleukin-6 and slope of monocyte human leukocyte antigen-dr a powerful association to predict the development of sepsis after major trauma早期的白细胞介素- 6和斜率的单核细胞人类白细胞antigen-dr一个强大的协会预测重大创伤后脓毒症的发展.pdfVIP

Early Interleukin-6 and Slope of Monocyte Human Leukocyte Antigen-DR: A Powerful Association to Predict the Development of Sepsis after Major Trauma ´ ´ 1,4 1,4 2 3 Aurelie Gouel-Cheron *, Bernard Allaouchiche , Caroline Guignant , Fanny Davin , Bernard Floccard1, Guillaume Monneret2,4, for AzuRea Group ´ ´ ˆ ˆ 1 Service de reanimation, Hopital Edouard Herriot - Hospices Civils de Lyon, Lyon, France, 2 Laboratoire d’immunologie cellulaire, Hopital Edouard Herriot - Hospices Civils ´ ´ ˆ ´ de Lyon, Lyon, France, 3 Laboratoire Commun de Recherche HCL-Biomerieux, Hopital Edouard Herriot - Hospices Civils de Lyon, Lyon, France, 4 EA 4174, Hemostase, ´ Inflammation et Sepsis, Hospices Civils de Lyon - Universite Claude Bernard Lyon 1, Lyon, France Abstract Objective: Major trauma is characterized by a pro-inflammatory response, followed by an immunosuppression. Recently, in trauma patients, the lack of recovery of monocyte Human Leukocyte Antigen DR (mHLA-DR, a biomarker of ICU-acquired immunosuppression) between days 1–2 and days 3–4 has been demonstrated to be independently associated with sepsis development. The main objective of this study was to determine whether early measurements