ecological niche modeling to estimate the distribution of japanese encephalitis virus in asia生态位建模估计日本脑炎病毒的分布在亚洲.pdfVIP

Ecological Niche Modeling to Estimate the Distribution of Japanese Encephalitis Virus in Asia 1 1 2 3 4 1 Robin H. Miller *, Penny Masuoka , Terry A. Klein , Heung-Chul Kim , Todd Somer , John Grieco 1 Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 2 65th Medical Brigade/USAMEDDACKorea, Unit 15281, Force Health Protection and Preventive Medicine, Yongsan Army Garrison, Seoul, Republic of Korea, 3 168th Multifunctional Medical Battalion, 65th Medical Brigade, Unit 15247, 5th Medical Detachment, Yongsan Army Garrison, Seoul, Republic of Korea, 4 NST, National Geospatial-Intelligence Agency, Fort Detrick, Maryland, United States of America Abstract Background: Culex tritaeniorhynchus is the primary vector of Japanese encephalitis virus (JEV), a leading cause of encephalitis in Asia. JEV is transmitted in an enzootic cycle involving large wading birds as the reservoirs and swine as amplifying hosts. The development of a JEV vaccine reduced the number of JE cases in regions with comprehensive childhood vaccination programs, such as in Japan and the Republic of Korea. However, the lack of vaccine programs or insufficient coverage of populations in other endemic countries leaves many people susceptible to JEV. The aim of this study was to predict the distribution of Culex tritaeniorhynchus using ecological niche modeling. Methods/Principal Findings: An ecological niche model was constructed using the Maxent program to map the areas with suitable environmental conditions for the Cx. tritaeniorhynchus vector. Program input consiste