dorsal visual pathway changes in patients with comitant extropia背视觉通路的变化患者comitant extropia.pdfVIP

Dorsal Visual Pathway Changes in Patients with Comitant Extropia 1 1 2 2 3 1 Xiaohe Yan , Xiaoming Lin *, Qifeng Wang , Yuanchao Zhang , Yingming Chen , Shaojie Song , Tianzi Jiang2 1 State Key Laboratory of Ophthalmology, ZhongShan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China, 2 National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People’s Republic of China, 3 Department of Radiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China Abstract Background: Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI). Principal Findings: Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/ cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa