原创力文档dissection of the role of pfemp1 and icam-1 in the sensing of plasmodium falciparum-infected erythrocytes by natural killer cells解剖的作用pfemp1和icam-1传感的疟原虫falciparum-infected红细胞自然杀伤细胞.pdfVIP
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dissection of the role of pfemp1 and icam-1 in the sensing of plasmodium falciparum-infected erythrocytes by natural killer cells解剖的作用pfemp1和icam-1传感的疟原虫falciparum-infected红细胞自然杀伤细胞
Dissection of the Role of PfEMP1 and ICAM-1 in the
Sensing of Plasmodium falciparum-Infected Erythrocytes
by Natural Killer Cells
1,2,3. 1,2,3. 4 ´ 1,2,3 5 1,2,3 6
Myriam Baratin , Sophie Roetynck , Bruno Pouvelle , Celine Lemmers , Nicola K. Viebig , Sofia Johansson , Philippe Bierling ,
5 ¨ 4 1,2,3,7 1,2,3
Artur Scherf , Jurg Gysin , Eric Vivier *, Sophie Ugolini *
´ ´
1 Aix-Marseille Universite, Faculte des Sciences de Luminy, Centre d’Immunologie de Marseille-Luminy (CIML), Marseille, France, 2 Institut National de
´ ´
la Sante et de la Recherche Medicale (INSERM), U631, Marseille, France, 3 Centre National de la Recherche Scientifique (CNRS), UMR6102, Marseille,
´ ´ ´ ´ ´
France, 4 Unite de Parasitologie Experimentale, Universite de la Mediterranee, Marseille, France, 5 Institut Pasteur and Centre National de la Recherche
´ ˆ ˆ
Scientifique (CNRS), Paris, France, 6 Etablissement franc¸ais du sang, Creteil, France, 7 Hopital de la Conception, Assistance Publique – Hopitaux de
Marseille, France
Background. Host innate immunity contributes to malaria clinical outcome by providing protective inflammatory cytokines
such as interferon-c, and by shaping the adaptive immune response. Plasmodium falciparum (Pf) is the etiologic agent of the
most severe forms of human malaria. Natural Killer (NK) cells are lymphocytes of the innate immune system that are the first
effectors to pro
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